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(1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol
| Product Name | (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol |
| Product Code | R00007504 |
| Chemical name | (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol |
| Synonyms | Abacavir Impurity E; Abacavir Impurities; Abacavir EP Impurity E |
| Impurity | Abacavir EP Impurity E |
| CAS Number | 208762-35-0 |
| Alternate CAS # | |
| Molecular form | C₁₄H₂₀N₆O |
| Appearance | Off-White Solid |
| Melting Point | >80°C (dec.) |
| Mol. Weight | 288.35 |
| Storage | -20°C Freezer |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Stability | |
| Category | Impurities, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, |
| Boiling Point | |
| Applications | (1R,3S)-3-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopentanemethanol (Abacavir EP Impurity E) is an impurity of Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Dangerous Goods Info | |
| References | (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008) |
| Extra Notes | |
| Documents (MSDS) | Download Document |
| Keywords | Buy 208762-35-0 | Purchase 208762-35-0 | Order 208762-35-0 | 208762-35-0 supplier | 208762-35-0 manufacturer | 208762-35-0 distributor | 208762-35-0 cost |
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